Macromolecular Bioscience 2017. 7. 21
Nanocomplexes of acid-transforming chitosan (ATC) and DNA fragments are endocytosed to Salmonella Typhimurium-infected macrophages. The mildly acidic environment in the phagolysosome converts ATC to an antimicrobial chitosan which is subsequently released from the nanocomplexes to effectively eradicates S. Typhimurium both in the phagolysosome and the cytoplasm via tackling a broad range of key microbial proteins. This is reported by Young Jik Kwon and co-workers in article number 2000408.
https://onlinelibrary.wiley.com/journal/16165195
Macromolecular Bioscience 2017. 7. 21
Nanocomplexes of acid-transforming chitosan (ATC) and DNA fragments are endocytosed to Salmonella Typhimurium-infected macrophages. The mildly acidic environment in the phagolysosome converts ATC to an antimicrobial chitosan which is subsequently released from the nanocomplexes to effectively eradicates S. Typhimurium both in the phagolysosome and the cytoplasm via tackling a broad range of key microbial proteins. This is reported by Young Jik Kwon and co-workers in article number 2000408.
https://onlinelibrary.wiley.com/journal/16165195